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KMID : 1161420150180111239
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Journal of Medicinal Food
2015 Volume.18 No. 11 p.1239 ~ p.1246
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Swine Dialyzable Spleen Extract as Antiviral Prophylaxis
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Merchand-Reyes Giovanna
Pavon Lenin
Perez-Sanchez Gilberto
Vazquez-Leyva Said
Salinas-Jazmin Nohemi
Velasco-Velazquez Marco
Medina-Rivero Emilio
Perez-Tapia Sonia Mayra
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Abstract
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Worldwide, the most highly consumed meat is of porcine origin. The production and distribution of swine meat are affected by diverse health matters, such as influenza and diarrhea, which cause head losses and require the use of antibiotics and other drugs in hog farms. To stimulate newborn piglet immune responses and increase resistance to infections, we developed a spray-drying technique to produce dried swine dialyzable spleen extract (sDSE), an immunomodulator. Based on the size-exclusion ultra performance liquid chromatography quantitative analysis, it was possible to recover up to 58% of the product after the drying process. The biological activity of orally administered dried sDSE increased mouse survival and induced cytokine production in a herpes infection model.
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KEYWORD
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immunoregulation, piglet food supplement, process development, ultra performance liquid chromatograph
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